Is DUXES a Wordle Word?

Yes. DUXES is a valid Wordle word.

It is not on the Wordle answer list, so it is unlikely to be a daily answer.

Plurals ending in S are almost never chosen as Wordle answers.

What does DUXES mean?

The top (male or female) academic student in a school, or in a year of school; the top student in a specified academic discipline.
A high-ranking commander in the Roman army, responsible for more than one legion.
The subject of a fugue, answered by the comes.

Definition from Wiktionary, available under the CC BY-SA license.

Starter word rating: WeakIn the top 65% of all valid Wordle words for testing common letters.
Vowels: U, E
Unique letters: 5 of 5
Common letters: E
Rare letters: X

Hard-mode trap: 8 valid words fit the pattern DU_ES. If you reach it, you may need several guesses to find the last letter.

Letter ratings use how often each letter appears in Wordle answers.

Tap its tiles to the colours Wordle showed, and the Wordle Solver lists every word that still fits, with the best next guess.