Is NIXES a Wordle Word?

Yes. NIXES is a valid Wordle word.

It is not on the Wordle answer list, so it is unlikely to be a daily answer.

Plurals ending in S are almost never chosen as Wordle answers.

What does NIXES mean?

To make something become nothing; to reject or cancel.“Nix the last order – the customer walked out.”
To destroy or eradicate.

Definition from Wiktionary, available under the CC BY-SA license.

Starter word rating: AverageIn the top 39% of all valid Wordle words for testing common letters.
Vowels: I, E
Unique letters: 5 of 5
Common letters: I, E
Rare letters: X

Hard-mode trap: 6 valid words fit the pattern _IXES. If you reach it, you may need several guesses to find the last letter.

Letter ratings use how often each letter appears in Wordle answers.

Tap its tiles to the colours Wordle showed, and the Wordle Solver lists every word that still fits, with the best next guess.